Heme Oxygenase-1 Inhibits HLA Class I Antibody-Dependent Endothelial Cell Activation.
Antibody-mediated rejection (AMR) is a key limiting factor for long-term graft survival in solid organ transplantation.Human leukocyte antigen (HLA) class I (HLA I) antibodies (Abs) play a major role in the pathogenesis of AMR via their interactions with HLA molecules on vascular endothelial cells (ECs).The antioxidant enzyme heme oxygenase (HO)-1